Organizers:
Russian Academy of Sciences
Russian Academy of Medical Sciences
Institute of Cytology, RAS
P.K. Anokhin Institute of Normal Physiology, RAMS
Umea University, Sweden
Russian Branch of International Academy of Sciences
Russian Neurochemical Society
Russian Physiological Society

Chairman:
Prof. B. Margulis

Co-chairman:
Acad. K. Sudakov

Committee:
L. Morozova-Roche
I. Guzhova
V. Sherstnev
M. Gruden

Location:
St Petersburg
Conference Hall, Russian Academy of Science, Universitetskaja nab, 5
Moscow
P.K. Anokhin Institute of Normal Physiology, RAMSMohovaya, st. 11, building 4

Dear Colleagues,
It is our great pleasure and honor to organize the International conference on "Protein complexes in normal and pathological conditions" aimed to exchange our knowledge and achievements in broadest field of fundamental science of biomolecules and their relationship to evolution and disease.We hope that the meeting will provide participants not only with information but also will give an opportunity to have a spectacular view of beautiful places of ancient and modern St Petersburg and Moscow.

   - Mechanisms of protein complexes formation.
   - Functional protein complexes and molecular networks.
   - Molecular control systems for protein folding. Chaperons and their biological role.
   - Protein misfolding and disease.
   - Clearance of protein aggregates.
   - Protein aggregates in informatory and regulatory mechanisms of systemic physiological functions formation.

June, 27, 2006
10.00-10.15 Opening ceremony
Chairman: B. Margulis
Welcome address: V. Parfenov, Director of Institute of Cytology RAN,

10.15-13.30 Chairmen: L. Thelander (Umea, Sweden) and A. Finkelshtein (Puschino, Russia)

C. Dobson (Cambridge, UK) Protein Misfolding and its Links with Human Disease.
T. Ny (Umea, Sweden) Physiological and pathological complexes of serpins.
Coffee break
L. Morozova-Roche (Umea, Sweden) Amyloid oligomers: structure and function
Discussion
O. Galzitskaya (Puschino, Russia) Prediction of amyloidogenic and unfolded regions in protein chain

13.30-18.00
Cultural programm

June, 28, 2006
10. 00-13.00
Cultural programm

13.30-18.00 Chairmen: R. Morimoto (Evanston, USA) and B. Margulis (St Petersburg, Russia)

R. Morimoto (Evanston, USA) Stress and misfolded proteins: modulators of neurodegenerative diseases and longevity.
M. Cheetham (London, UK) DnaJ proteins and neurodegeneration.
Coffee break
R. Sewell (Cardiff, UK) Potential therapeutic approaches to amyloidogenic neurodegenerative diseases.
I. Guzhova (St Petersburg, Russia) The route to the application of Hsp70 chaperone in the therapy of neurodegenerative diseases.
M. Gruden (Moscow, Russia) Immune approaches in investigation of amyloid-related neurodegenerative diseases.
V. Filimonov (Pushchino, Russia) Reversible oligomerization of the partially folded λ Cro repressor
Discussion

June, 29, 2006
10.00-13.00
Cultural program

13.30-18.30 Chairmen: C. Dobson (Cambridge, UK) and E. Permyakov (Pushchino, Russia).

S. Inge-Vechtomov, A.P. Galkin (St Petersburg, Russia) Yeast prions and proteomic nets.
L. Thelander (Umea, Sweden)DNA replication and repair from the perspective of ribonucleotide reductase.
Coffee break
А. Finkelshtein (Pushchino, Russia) Simple models for beta-structure formation in beta-sheets and in amyloid fibers: similarity and difference.
E. Permyakov (Pushchino, Russia) Electrostatic interactions of α-lactalbumin with histones and poly-aminoacids.
Coffee break
I. Kostanyan (Moscow, Russia) Protective effects of peptide HLDF6 in cell and animal models of Аβ-peptide toxicity.
S. Tolpygo (Moscow, Russia) Peptide-protein conjugates: experimental and clinical aspects.
E.B. Zhulina (St Petersburg, Russia) Modeling neurofilament structure using polymer brush theory.
Discussion

Dinner on a Boat

June, 30, 2006
10.30-14.00
Cultural program, treasures of Kremlin

14.30-17.00
Round-table with lunch "Protein complexes: structure and physiological function"
Chairman: Acad. K. Sudakov, Director of Institute of Normal Physiology. All participants.

18.00
Cultural program

July, 1, 2006
10.00-12.00
Visit to the memorial museum of a prominent Russian physiologist I. M. Sechenov and laboratories of P. K. Anokhin Institute of Normal Physiology RAMS.
General discussion and closing the conference.

13.00-18.00
Cultural program